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The metabolism of 7‐ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease.
Author(s) -
Woodhouse KW,
Mitchison HC,
Mutch E,
Wright PD,
Rawlins MD,
James OF
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02801.x
Subject(s) - microsome , primary biliary cirrhosis , drug metabolism , cirrhosis , metabolism , liver disease , medicine , endocrinology , biology , drug , xenobiotic , enzyme , pharmacology , biochemistry
Using 7‐ethoxycoumarin as a probe substrate, microsomal monoxygenase activity has been measured in liver tissue from patients with primary biliary cirrhosis (PBC) of varying histological severity, and in histologically normal control tissue. Interindividual variation in enzyme activity was considerable, and in no histological category was the activity significantly different to control. We conclude that: (a) in PBC, hepatic microsomal monoxygenase activity is determined primarily by factors other than the histological severity of the liver disease, and (b) studies of xenobiotic metabolism in patients with liver disease should specify the nature of the underlying disease process.