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Gastrointestinal transit of Oros drug delivery systems in healthy volunteers: a short report.
Author(s) -
John VA,
Shotton PA,
Moppert J,
Theobald W
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02763.x
Subject(s) - oxprenolol , drug , metoprolol , gastrointestinal transit , medicine , transit (satellite) , pharmacology , gastrointestinal tract , propranolol , public transport , political science , law
Transit times for oxprenolol and metoprolol Oros drug delivery systems through the gastrointestinal tract have been measured in 35 individuals in six separate studies. A total of 45 systems were recovered in a median time of 27.4 h; individual transit times varied from 5.1 to 58.3 h. The residual amount of drug in recovered systems was inversely related to transit time and corresponded closely with the amount estimated from in vitro dissolution profiles.