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Influence of food intake on plasma oxprenolol concentrations following oral administration of conventional and Oros preparations.
Author(s) -
John VA,
Smith SE
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02761.x
Subject(s) - postprandial , oxprenolol , pharmacokinetics , drug , oral administration , pharmacology , plasma concentration , dosing , absorption (acoustics) , chemistry , in vivo , plasma levels , meal , evening , medicine , endocrinology , biology , insulin , physics , microbiology and biotechnology , astronomy , blood pressure , acoustics
Plasma concentrations of oxprenolol have been measured in six healthy volunteers following single‐dose oral administration of the drug in conventional and Oros dosage forms in fasting and postprandial states. After the Oros system, plasma concentrations reached peaks in most subjects at 3‐8 h after dosing and were approximately 25% of those achieved with the conventional tablet. Plasma concentrations were well sustained for at least 24 h. A secondary peak occurred consistently at 12 h, possibly reflecting a transient change in clearance and/or distribution of the drug following the evening meal. With each formulation, plasma drug concentration profiles following administration in the fasting state did not differ significantly from those obtained when the drug was given postprandially. Drug absorption in vivo corresponded reasonably closely with in vitro drug release from the Oros system.