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The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.
Author(s) -
Hirtz J
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02746.x
Subject(s) - absorption (acoustics) , current (fluid) , drug , gastrointestinal transit , medicine , pharmacology , metoprolol , intensive care medicine , engineering , physics , optics , electrical engineering
The various mechanisms which have been advanced to explain drug absorption are critically reviewed and the limitations of current theories are discussed. Various techniques for investigating drug absorption and transit through the gut are presented, and the results obtained with metoprolol are briefly considered to illustrate the potential of some of these methods.