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A double‐blind comparison of alprazolam, diazepam and placebo in the treatment of anxious out‐patients.
Author(s) -
Davison K,
Farquharson RG,
Khan MC,
Majid A
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02741.x
Subject(s) - alprazolam , diazepam , placebo , anxiolytic , antidepressant , neuroticism , medicine , double blind , anti anxiety agents , depression (economics) , anesthesia , anxiety , pharmacology , psychology , psychiatry , social psychology , alternative medicine , personality , pathology , economics , macroeconomics
In a double‐blind 28‐day comparison of alprazolam, diazepam and placebo, alprazolam 1.5‐3 mg/day was of equivalent anxiolytic effect to 15‐30 mg diazepam/day and there was some evidence of antidepressant activity by alprazolam, but not diazepam, in neurotic depression. No serious side‐effects or laboratory abnormalities were encountered.