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The use of benzodiazepines in depression.
Author(s) -
Johnson DA
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02740.x
Subject(s) - tricyclic , alprazolam , antidepressant , depression (economics) , tricyclic antidepressant , medicine , onset of action , pharmacology , psychiatry , anxiety , economics , macroeconomics
In clinical practice the benzodiazepines are prescribed almost as frequently as the tricyclic antidepressants for the treatment of depression. The therapeutic effects of the benzodiazepines and tricyclic antidepressants in depression have been compared in only 29 double‐blind studies. The antidepressants proved overwhelmingly superior with only one study (alprazolam) even suggesting a possible parity of action. A symptom response analysis failed to show any true antidepressant action for the benzodiazepines. No clear indication for the use of a combination of drugs was revealed, although certain symptoms may show a more rapid response initially with combination therapy.