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A placebo controlled comparison of the effects of pirenzepine and amitriptyline on the tyramine pressor test in healthy volunteers.
Author(s) -
Wilkins MR,
Wynne RD,
Kendall MJ
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02722.x
Subject(s) - amitriptyline , pirenzepine , placebo , tyramine , pharmacology , cold pressor test , tricyclic , medicine , blood pressure , pressor response , anesthesia , endocrinology , antagonist , heart rate , receptor , alternative medicine , pathology
The possibility of an interaction between pirenzepine, an antimuscarinic drug structurally similar to the tricyclic antidepressants, and sympathomimetic agents was investigated in a group of healthy volunteers. The effect of pirenzepine on response to intravenous tyramine was compared with that of placebo and amitriptyline. The mean dose of tyramine required to elevate systolic blood pressure by 30 mm Hg was 5.0 mg (+/‐ s.d. 0.8) after placebo, 5.1 mg (+/‐ 1.0) after pirenzepine and 11.3 mg (+/‐ 1.8) after amitriptyline. These results suggest that pirenzepine will not potentiate the effects of concurrently administered sympathomimetic drugs.