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A comparison of the effect of paroxetine and amitriptyline on the tyramine pressor response test.
Author(s) -
Hassan SM,
Wainscott G,
Turner P
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02700.x
Subject(s) - amitriptyline , paroxetine , tyramine , pharmacology , pressor response , sedation , medicine , anesthesia , chemistry , endocrinology , serotonin , blood pressure , heart rate , receptor
The effect of single and repeated dosing of paroxetine on the in vivo noradrenaline uptake process, as determined by tyramine pressor response tests, was evaluated in normal healthy subjects. No statistically significant inhibition of the uptake process was observed for paroxetine, nor did it produce sedation or dryness of the mouth, though effects were observed for amitriptyline.