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Aztreonam in human serum and breast milk.
Author(s) -
Fleiss PM,
Richwald GA,
Gordon J,
Stern M,
Frantz M,
Devlin RG
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02677.x
Subject(s) - aztreonam , serum concentration , breast milk , medicine , human breast milk , intramuscular injection , pharmacokinetics , absorption (acoustics) , oral administration , antibiotics , chemistry , biochemistry , physics , antibiotic resistance , imipenem , acoustics
Serum and milk concentrations of aztreonam were studied in 12 lactating, healthy subjects over the 8 h period after the administration of a single intramuscular or intravenous 1 g dose. Milk concentrations of aztreonam were found to be much lower than serum concentrations at all time points after both routes of injection. Peak milk concentrations of aztreonam averaged less than 1% of peak serum concentrations. Times to peak concentrations averaged 6 and 10 times longer in milk than in serum after intramuscular and intravenous injections, respectively. The low milk levels, as well as the previously determined poor oral absorption of aztreonam, suggest a low risk of untoward effects in the nursing infant.