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The effects of age and smoking on the plasma protein binding of lignocaine and diazepam.
Author(s) -
Davis D,
Grossman SH,
Kitchell BB,
Shand DG,
Routledge PA
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02641.x
Subject(s) - diazepam , orosomucoid , plasma protein binding , albumin , blood proteins , medicine , endocrinology , chemistry , plasma concentration , ageing , blood plasma , pharmacology , glycoprotein , biochemistry
In 63 healthy ambulant subjects 18 to 88 years of age, the plasma protein binding of diazepam (principally bound to albumin) decreased with age. Diazepam binding in plasma correlated positively with plasma albumin concentration which also decreased with age. In contrast, the plasma protein binding of the basic drug, lignocaine (predominantly bound to alpha 1‐acid glycoprotein [AAG]), tended to increase slightly with age. Lignocaine binding in plasma correlated positively with plasma AAG concentration which also increased slightly with age. Smoking did not affect the plasma protein binding of diazepam or lignocaine or the plasma concentrations of albumin, AAG or nonesterified fatty acids. These results suggest that age‐related changes in plasma protein binding of lignocaine and diazepam are determined in part by age‐related changes in the concentrations of the binding proteins in plasma. The ageing process alone causes only small changes in the plasma protein binding of these drugs compared with the effect of disease states, however.