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Strength of the human mixed lymphocyte reaction (MLR) and its suppression by azathioprine or 6‐mercaptopurine.
Author(s) -
AlSafi SA,
Maddocks JL
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02622.x
Subject(s) - azathioprine , mercaptopurine , mixed lymphocyte reaction , immunology , lymphocyte , medicine , pharmacology , chemistry , immune system , t cell , disease
Azathioprine (36 microM) had a significantly (P less than 0.00003) greater inhibitory effect on human MLR responses below 20,000 counts/min than on responses above 20,000 counts/min. In contrast, 6‐ mercaptopurine (100 microM) had a similar suppressive effect on MLR responses below and above 20,000 counts/min suggesting it has a different mode of action to azathioprine.