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Thrombocytopenia and leucopenia with mianserin‐dependent antibodies.
Author(s) -
Stricker BH,
Barendregt JN,
Claas FH
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02621.x
Subject(s) - mianserin , immunology , platelet , antibody , lysis , medicine , platelet lysate , immunofluorescence , antibody dependent cell mediated cytotoxicity , thrombocytopenic purpura , receptor , monoclonal antibody , serotonin
By indirect immunofluorescence specific mianserin‐dependent antibodies were detected against platelets but not against granulocytes in the serum of a patient with thrombocytopenic purpura and mild leucopenia. A complement‐mediated cytotoxicity assay demonstrated 70% lysis of granulocytes but no lysis of platelets, only when mianserin was added to the medium. We suggest that, at least in some patients, mianserin may cause blood disorders by an immunologically‐mediated mechanism.