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Inhibition of food stimulated acid secretion by misoprostol, an orally active synthetic E1 analogue prostaglandin.
Author(s) -
Ramage JK,
Denton A,
Williams JG
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb02606.x
Subject(s) - misoprostol , prostaglandin e1 , prostaglandin analogue , prostaglandin , pharmacology , chemistry , prostaglandin antagonist , oral administration , basal (medicine) , dosing , endocrinology , medicine , biology , biochemistry , pregnancy , genetics , abortion , insulin
The effect of 200 micrograms misoprostol (a synthetic prostaglandin E1 analogue) on food stimulated intragastric acidity has been monitored over a 9 h period in 16 normal volunteers. Misoprostol caused a significant inhibition of intragastric acidity for 2 h post‐dosing, but no significant effect was seen thereafter on either basal or food stimulated acidity.

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