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Cortisol and dexamethasone elimination during treatment with cimetidine.
Author(s) -
Peden NR,
Rewhorn I.,
Champion MC,
Mussani R.,
Ooi TC
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb05030.x
Subject(s) - cimetidine , dexamethasone , placebo , pharmacokinetics , medicine , pharmacology , dexamethasone sodium phosphate , endogeny , hydrocortisone , endocrinology , alternative medicine , pathology
In a randomised cross‐over study of treatment for 7 days with cimetidine 600 mg twice daily and placebo, cimetidine had no effect on the pharmacokinetics of a single intravenous dose of dexamethasone sodium phosphate. Likewise the elimination characteristics of endogenous cortisol in the dexamethasone suppressed state were not affected by cimetidine.