Premium
Pharmacodynamics and pharmacokinetics of digoxin in the presence of lithium.
Author(s) -
Cooper SJ,
Kelly JG,
Johnston GD,
Copeland S.,
King DJ,
McDevitt DG
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb05016.x
Subject(s) - digoxin , pharmacokinetics , lithium (medication) , pharmacodynamics , pharmacology , lithium carbonate , sodium , electrolyte , drug interaction , medicine , chemistry , heart failure , ion , organic chemistry , electrode , ionic bonding
Previous biochemical and clinical data suggest there may be an interaction between digoxin and lithium. The pharmacodynamics and pharmacokinetics of an intravenous infusion of digoxin were studied in six male subjects before and after 2 weeks treatment with lithium carbonate. The effects of lithium on sodium pump activity, intracellular electrolytes and extracellular electrolytes were studied. No significant interaction between digoxin and lithium was found. No significant effects of lithium on sodium pump activity or electrolyte concentrations were found.