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Nicotine and cotinine concentrations in serum and milk of nursing smokers.
Author(s) -
Luck W.,
Nau H.
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb05014.x
Subject(s) - cotinine , nicotine , medicine , linear correlation , serum concentration , zoology , chemistry , endocrinology , biology , statistics , mathematics
Analysis of 44 milk samples from 23 nursing smokers revealed that there was a linear correlation between nicotine concentrations in serum and in milk (r = 0.70). The nicotine concentrations in milk were considerably higher than the corresponding serum concentrations: milk/serum concentration ratio = 2.92 +/‐ 1.09; (n = 44). There was also a linear correlation between the cotinine concentrations in serum and in milk (r = 0.89). The cotinine concentrations in milk were lower than the corresponding serum concentrations: milk/serum concentration ratio = 0.78 +/‐ 0.19; (n = 44). The direct comparison between the half‐ lives of nicotine in serum and in milk was possible in five nursing smokers. The half‐life of nicotine in milk was determined in four additional smoking mothers. The half‐life of nicotine in milk t 1/2 = 97 +/‐ 20 min slightly exceeded the half‐life of nicotine in serum t 1/2 = 81 +/‐ 9 min; the difference between these two values was not statistically significant (P greater than 0.05). Cotinine concentrations remained fairly consistent during a 4 h interval without smoking.