Premium
Bronchodilator responses to nebulised ipratropium and salbutamol singly and in combination in chronic bronchitis.
Author(s) -
Chan CS,
Brown IG,
Kelly CA,
Dent AG,
Zimmerman PV
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb05008.x
Subject(s) - bronchodilatation , ipratropium , salbutamol , bronchodilator , medicine , ipratropium bromide , anesthesia , chronic bronchitis , bronchitis , asthma
A placebo controlled study compared the magnitude and duration of bronchodilatation produced by nebulised salbutamol (5 mg) and ipratropium (0.5 mg) singly and in combination in twenty patients with chronic bronchitis (mean baseline FEV1 was 33% predicted). The onset of action, of both nebulised salbutamol and ipratropium given singly, occurred within 15 min. Both agents produced a similar degree of bronchodilatation. In combination both the magnitude and duration of the bronchodilatation produced was significantly greater than with either agent alone.