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Nifedipine increases and glyceryl trinitrate decreases apparent liver blood flow in normal subjects.
Author(s) -
Feely J.
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb05003.x
Subject(s) - nifedipine , indocyanine green , vasodilation , blood pressure , medicine , blood flow , anesthesia , mean arterial pressure , heart rate , surgery , calcium
The effects of sublingual nifedipine (10 mg) and of glyceryl trinitrate (500 micrograms), which produce arterial and venous vasodilatation respectively, on indocyanine green estimated apparent liver blood flow (LBF) were studied in six healthy volunteers. Nifedipine significantly increased (33 +/‐ 12%; mean +/‐ s.e. mean) and glyceryl trinitrate significantly reduced (18 +/‐ 3%) LBF. There was a positive relationship (r = 0.92, P less than 0.05) between the reduction in mean arterial pressure produced by nifedipine and the percentage increase in LBF. These results show that single doses of nifedipine and glyceryl trinitrate significantly alter LBF.