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The effect of the non‐steroidal anti‐inflammatory drug choline magnesium trisalicylate on gastric mucosal cell exfoliation.
Author(s) -
Mitchell KG,
Hearns J.,
Crean GP
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb04994.x
Subject(s) - aspirin , placebo , magnesium , medicine , choline , pharmacology , drug , nausea , gastroenterology , exacerbation , chemistry , pathology , alternative medicine , organic chemistry
Gastric mucosal cell exfoliation was measured in 10 normal subjects taking choline magnesium trisalicylate (CMT), aspirin and placebo. Both drugs resulted in significantly elevated rates of exfoliation although the serum salicylate levels achieved with aspirin were lower than those achieved by CMT. Side‐effects of tinnitus, nausea and increased faecal blood loss were more common while subjects were taking CMT.