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Effects of antidepressants on skilled performance.
Author(s) -
Linnoila M,
Johnson J,
Dubyoski K,
Buchsbaum MS,
Schneinin M,
Kilts C
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02589.x
Subject(s) - desipramine , amitriptyline , pharmacology , pharmacodynamics , ethanol , adverse effect , medicine , pharmacokinetics , chemistry , antidepressant , biochemistry , hippocampus
Effects of amitriptyline 50 mg, desipramine 100 mg, and zimelidine 200 mg alone and in combination with ethanol 0.8 g/kg were investigated in healthy, male volunteers. Amitriptyline increased body sway and impaired tracking as well as information processing. It had an additive deleterious pharmacodynamic interaction with ethanol. Desipramine and zimelidine were free of adverse effects on performance and did not have significant interactions with ethanol. The dose of ethanol used in the present study did not inhibit biotransformation of the antidepressants.