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Ambulatory motor activity monitoring to study the timecourse of hypnotic action.
Author(s) -
Borbely AA
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02585.x
Subject(s) - flurazepam , triazolam , flunitrazepam , temazepam , ambulatory , midazolam , hypnotic , medicine , anesthesia , onset of action , pharmacology , benzodiazepine , sedation , receptor
A solid state activity monitor worn on the wrist was used to study the effect of flunitrazepam, flurazepam, temazepam, triazolam and midazolam. All compounds reduced motor activity in the first half, but only flunitrazepam and flurazepam had an effect during the second half of the bed rest period. Ambulatory activity monitoring is an unobtrusive and simple method for investigating timecourse of action.