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Dose‐response studies with pancuronium, vecuronium and their combination.
Author(s) -
Ferres CJ,
Mirakhur RK,
Pandit SK,
Clarke RS,
Gibson FM
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02568.x
Subject(s) - long term potentiation , anesthesia , medicine , pharmacology , receptor
Pancuronium, vecuronium and a combination of these were administered in an incremental fashion to study any potentiation of effect with the combination of the two relaxants. The ED95 (dose producing a 95% block) of the combination was 29 micrograms kg‐1 for each component in comparison to 57 micrograms kg‐1 for vecuronium and 59 micrograms kg‐1 for pancuronium. The dose‐response curves for the three groups did not differ from each other and no potentiation was demonstrated.