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Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.
Author(s) -
Jawad S,
Richens A,
Oxley J
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02558.x
Subject(s) - clobazam , pharmacokinetics , medicine , pharmacology , anti anxiety agents , epilepsy , anesthesia , psychiatry , anxiety
The pharmacokinetics of clobazam were studied in six healthy volunteers and six age and sex matched enzyme‐induced epileptic patients. In the epileptic patients the area under the plasma concentration‐time curve for clobazam was significantly smaller and the area under the plasma concentration‐time curve for N‐desmethylclobazam was significantly greater than in the healthy volunteers. Plasma N‐desmethylclobazam concentrations were found to be much higher than those of clobazam in the epileptic patients, raising the possibility that the antiepileptic properties of clobazam are to be attributed more to its metabolite than the parent drug.

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