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Effect of migraine attacks on paracetamol absorption.
Author(s) -
Tokola RA,
Neuvonen PJ
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02557.x
Subject(s) - migraine , nausea , medicine , absorption (acoustics) , gastric emptying , anesthesia , pharmacokinetics , acetaminophen , area under the curve , gastroenterology , stomach , materials science , composite material
The absorption of effervescent paracetamol (1000 mg) was investigated in nine female patients during a migraine attack and in the same patients when headache free. Migraine attack decreased (P less than 0.05) the areas under the serum paracetamol concentration‐time curves (AUC) of 0‐2 h, 0‐4 h and 0‐6 h and the peak serum concentration. The severity of nausea correlated significantly with the decrease in the AUC values. Our results support findings of delayed gastric emptying in migraine attacks. Both a delay and an impairment of drug absorption may follow.