Premium
Propranolol concentrations in blood serum, seminal plasma and saliva in man after a single oral dose.
Author(s) -
Mahajan P,
Grech ED,
Pearson RM,
Ridgway EJ,
Turner P
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02554.x
Subject(s) - saliva , propranolol , semen , dosing , endocrinology , medicine , propranolol hydrochloride , sperm motility , sperm , chemistry , pharmacology , andrology
A single dose of 80 mg racemic propranolol hydrochloride was administered by mouth to six healthy male volunteers. The mean concentration achieved in seminal plasma at 2 h after dosing was almost identical to that in blood serum. The concentrations of propranolol in seminal plasma and saliva were much less than those known to reduce sperm motility by 50% in vitro. The concentrations in saliva did not reflect those in blood serum. Propranolol in the dose administered in this study is unlikely to affect fertility by its presence in saliva or semen.