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Effects of beta‐adrenoceptor blockade on exercise performance and respiratory response in healthy, physically untrained humans.
Author(s) -
Violante B,
Buccheri G,
Brusasco V
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02549.x
Subject(s) - propranolol , placebo , blockade , heart rate , medicine , respiratory minute volume , exertion , respiratory system , respiratory exchange ratio , ventilation (architecture) , physical exercise , anesthesia , blood pressure , receptor , mechanical engineering , alternative medicine , pathology , engineering
The effects of propranolol 80 mg orally were compared with those of placebo on the response to a stepwise increasing exercise test in 17 healthy and physically untrained volunteers, of whom eight were female. Propranolol showed no significant effects on maximum work rate or perceived exertion rate. However, submaximal O2 uptake, CO2 output and minute ventilation tended to be lower after propranolol than after placebo. It is concluded that in subjects with a low work capacity, beta‐adrenoceptor blockade does not impair maximal exercise capacity. The mechanisms underlying changes in respiratory response to exercise after propranolol are not fully explained. However, changes in substrate utilisation, the reduction in cardiac output and an alteration in respiratory drive may all be involved.