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Cardiovascular and biochemical responses to nebulised salbutamol in normal subjects.
Author(s) -
Smith SR,
Ryder C,
Kendall MJ,
Holder R
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02520.x
Subject(s) - salbutamol , medicine , blood pressure , bronchodilator , diuretic , heart rate , anesthesia , placebo , cardiology , asthma , alternative medicine , pathology
When conventional therapeutic doses of nebulised salbutamol were given to normal volunteers, there was a significant rise in pulse rate, systolic blood pressure and plasma glucose and a significant fall in diastolic blood pressure and serum potassium in comparison with placebo. Such changes may be potentially hazardous in certain situations. Patients with airways obstruction due to chronic bronchitis who have coexistent ischaemic heart disease or diuretic induced hypokalaemia may be at particular risk from the unwanted cardiovascular and biochemical responses to nebulised salbutamol.