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Comparative bioavailability of tetracycline and lymecycline.
Author(s) -
SjolinForsberg G,
Hermansson J
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02500.x
Subject(s) - bioavailability , tetracycline , tetracycline hydrochloride , urine , pharmacokinetics , dosing , chemistry , chromatography , pharmacology , medicine , antibiotics , biochemistry
The relative bioavailability of lymecycline and tetracycline hydrochloride was compared in 12 healthy volunteers in a double‐blind cross‐over study using a high performance liquid chromatographic method for plasma and urine analyses. A statistical significant difference in favour of tetracycline hydrochloride was found concerning the mean AUC and the mean lag time. The relative bioavailability of lymecycline was only 70% compared with tetracycline in multiple dosing (19.13 +/‐ 5.39 micrograms ml‐1 h and 27.22 +/‐ 6.26 micrograms ml‐1 h respectively) and 80% in a single dose (21.88 +/‐ 4.23 micrograms ml‐1 h and 26.91 +/‐ 6.01 respectively) and the mean lag time of tetracycline was only 60% compared with lymecycline.