Premium
Lack of a pharmacokinetic interaction between nifedipine and the beta‐ adrenoceptor blockers metoprolol and atenolol.
Author(s) -
Kendall MJ,
Jack DB,
Laugher SJ,
Lobo J,
Smith S Rolf
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02472.x
Subject(s) - atenolol , metoprolol , nifedipine , pharmacokinetics , pharmacology , beta (programming language) , drug , medicine , drug interaction , urine , propranolol , blood pressure , calcium , computer science , programming language
Nifedipine, metoprolol and atenolol were administered orally to young, healthy volunteers. Each drug was given alone and nifedipine was also given with both beta‐adrenoceptor blockers. Each drug was given for 3 days immediately before the study days. Plasma and urine drug concentrations were measured and the relevant pharmacokinetic parameters calculated. No pharmacokinetic interaction between nifedipine and the beta‐adrenoceptor blockers was revealed.