Premium
Placental transfer of metronidazole and tinidazole in early human pregnancy after a single infusion.
Author(s) -
Karhunen M
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02465.x
Subject(s) - tinidazole , metronidazole , placenta , abortion , medicine , pregnancy , serum concentration , gestation , pharmacology , andrology , fetus , antibiotics , biology , microbiology and biotechnology , genetics
Concentrations of metronidazole and tinidazole were analysed in mother's serum, placental tissue and foetal tissue after a single intravenous infusion of 500 mg of either drug in 21 patients who underwent a first trimester legal abortion. At the time of the evacuation (60 min from the start of the infusion) the concentrations of metronidazole and tinidazole in serum were 13.6 +/‐ 0.6 micrograms/ml and 13.2 +/‐ 0.4 micrograms/ml, respectively. In foetal tissue the concentrations of metronidazole and tinidazole reached 66% and 58%, and in placental tissue 26% and 37%, of the respective serum values.