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The role of the intestinal microflora in the reductive metabolism of acenocoumarol in man.
Author(s) -
Thijssen HH,
Baars LG,
Hazen MJ,
Bogaard AE
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02463.x
Subject(s) - acenocoumarol , urine , metabolite , metabolism , pharmacology , chemistry , absorption (acoustics) , pharmacokinetics , oral administration , feces , warfarin , biochemistry , medicine , biology , microbiology and biotechnology , physics , acoustics , atrial fibrillation
Although the oral anticoagulant acenocoumarol (AC) is very effectively metabolized by the intestinal microflora to its amino metabolite, under clinical conditions this route of AC‐disposition is of no importance because the compound is rapidly absorbed from its pharmaceutical application form. Only when the gastro‐intestinal absorption is retarded, for instance by using a capsule as vehiculum, are appreciable amounts of reduced metabolites recovered in urine.