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Stereoselective binding of propranolol enantiomers to human alpha 1‐ acid glycoprotein and human plasma.
Author(s) -
Albani F,
Riva R,
Contin M,
Baruzzi A
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02462.x
Subject(s) - orosomucoid , propranolol , enantiomer , alpha (finance) , stereoselectivity , chemistry , albumin , glycoprotein , plasma protein binding , blood proteins , blood plasma , serum albumin , biochemistry , stereochemistry , chromatography , endocrinology , biology , medicine , construct validity , nursing , patient satisfaction , catalysis
The binding of propranolol enantiomers to human albumin (ALB), alpha 1‐ acid glycoprotein (alpha 1‐AGP) and plasma was studied. (‐) propranolol is more bound than (+)propranolol to alpha 1‐AGP (P less than 0.001) and to plasma (P less than 0.05). In solutions containing ALB at a constant concentration (580 mumol/l) and alpha 1‐AGP at increasing concentrations, the binding of both isomers increases but the stereo selectivity is evident throughout the alpha 1‐AGP concentration range examined (25‐100 mumol/l).