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Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.
Author(s) -
Miners JO,
Robson RA,
Birkett DJ
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02461.x
Subject(s) - clofibric acid , glucuronidation , medicine , free fraction , endocrinology , drug , clofibrate , mestranol , chlormadinone acetate , oral administration , drug interaction , ethinylestradiol , pharmacology , pharmacokinetics , chemistry , population , family planning , microsome , research methodology , enzyme , biochemistry , environmental health
The disposition of clofibric acid, a drug metabolised largely by glucuronidation, was studied in eight males, eight females and eight females receiving oral contraceptive steroids (OCS). Clofibric acid plasma clearance was not significantly different in males compared to the control female group but was 48% greater (P less than 0.01) in women receiving OCS compared to non‐pill using females. This difference was due to an alteration in clofibric acid metabolic clearance as there were no differences between the groups in clofibric acid free fraction. Along with previous data the results suggest that induction of drug glucuronidation by OCS may be of clinical importance, although any sex‐ related differences are unlikely to be of clinical significance.