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Maintenance therapy after i.v. administration of disopyramide with an oral sustained release preparation, a pharmacokinetic study.
Author(s) -
Liem KL,
Hollander JM
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02457.x
Subject(s) - disopyramide , pharmacokinetics , medicine , oral administration , pharmacology , bolus (digestion) , intravenous bolus , anesthesia , surgery
The blood levels in 20 patients were studied during the change from parenteral administration of disopyramide to an oral sustained release preparation containing the same active substance. From this study it is concluded that 100 mg i.v. bolus injection of disopyramide can safely be followed by the immediate administration of one sustained release tablet containing 250 mg disopyramide. In case of an i.v. infusion (0.4 mg kg‐1h‐1) it seems wise not to start earlier with the administration of the sustained release preparation than at the moment of stopping the infusion.