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The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients.
Author(s) -
Salvetti A,
Pedrinelli R,
Alberici P,
Magagna A,
AbdelHaq B
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02442.x
Subject(s) - atenolol , sulindac , medicine , pharmacology , crossover study , ibuprofen , blood pressure , nonsteroidal , alternative medicine , pathology , placebo
Indomethacin and sulindac were used as tools to study the role of renal and/or systemic prostaglandins in the pharmacological response to atenolol. Patients receiving chronic treatment with atenolol 100 mg received indomethacin 50 mg twice daily or sulindac 200 mg twice daily in a randomised crossover trial. Indomethacin significantly reduced the antihypertensive action of atenolol while sulindac had no effect. The role that systemic and/or renal prostaglandins may play in the antihypertensive action of atenolol is discussed with reference to renal PGI2 production and inhibition of platelet cyclo‐oxygenase.