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The interaction of cigarette smoking and beta‐adrenoceptor blockade.
Author(s) -
Fox K,
Deanfield J,
Krikler S,
Ribeiro P,
Wright C
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02437.x
Subject(s) - atenolol , propranolol , placebo , medicine , blockade , cigarette smoking , urine , heart rate , beta (programming language) , endocrinology , blood pressure , alternative medicine , receptor , pathology , computer science , programming language
The importance of the interaction between smoking and propranolol (metabolised in the liver) and atenolol (excreted almost entirely in the urine) was investigated in a double‐blind placebo‐controlled trial. Resting and exercise heart rates were significantly greater during smoking than no‐smoking phases. Atenolol and propranolol significantly improved ST segment response after exercise whether or not the patients were smoking. Plasma propranolol significantly increased when patients stopped smoking whereas there was no such change in atenolol levels.