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Beta‐adrenoceptor blocker pharmacokinetics and the oral contraceptive pill.
Author(s) -
Kendall MJ,
Jack DB,
Quarterman CP,
Smith SR,
Zaman R
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02435.x
Subject(s) - pill , pharmacokinetics , adrenergic beta antagonists , medicine , pharmacology , beta adrenoceptor , adrenergic receptor , propranolol , receptor
Higher AUC and Cmax values were obtained for metoprolol, oxprenolol and propranolol in groups receiving the low‐dose oestrogen‐ethinyl oestradiol oral contraceptive, but statistical significance was reached only with metoprolol AUC. The oral contraceptive had the opposite effect on acebutolol AUC and Cmax but this was not significant. The oral contraceptive had no detectable effects on the tmax and t 1/2 values of any of the beta‐adrenoceptor blockers.