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Saliva concentrations of isosorbide dinitrate, isosorbide 2‐mononitrate and isosorbide 5‐mononitrate.
Author(s) -
Taylor IW,
Major RM,
Chasseaud LF,
Taylor T
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02394.x
Subject(s) - isosorbide dinitrate , isosorbide , isosorbide mononitrate , pharmacology , pharmacokinetics , saliva , medicine , chemistry , anesthesia , organic chemistry
Correlations between saliva and plasma concentrations of isosorbide dinitrate (ISDN), and its active metabolites, isosorbide 2‐mononitrate (2‐ISMN) and isosorbide 5‐mononitrate (5‐ISMN) were examined. In the case of 5‐ISMN (r = 0.98, P less than 0.01), saliva concentrations are probably reliable indices of the plasma concentrations of this drug and their measurement should provide a useful non‐invasive procedure to assess compliance during the clinical use of products containing either ISDN or 5‐ISMN: it may also be helpful in assessing the clinical pharmacokinetics of 5‐ISMN. Less satisfactory correlations were obtained for ISDN (r = 0.84) and 2‐ISMN (r = 0.83).