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Influence of chronic dosing on theophylline clearance.
Author(s) -
Efthimiou H,
Morgan DJ,
IoannidesDemos L,
Raymond K,
McLean AJ
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02385.x
Subject(s) - theophylline , dosing , medicine , pharmacokinetics , bronchodilator , steady state (chemistry) , anesthesia , pharmacology , chemistry , asthma
Theophylline clearance was studied in normal healthy volunteers before and after chronic oral dosing. Oral theophylline clearance showed a significant decrease (P less than 0.001) from 59.3 +/‐ 6.48 ml/min (mean +/‐ s.e. mean, n = 10) to 48.0 +/‐ 6.4 ml/min. Steady‐state intravenous clearance decreased by 26 +/‐ 2% from 55.1 +/‐ 7.7 ml/min to 41.0 +/‐ 5.96 ml/min (mean +/‐ s.e. mean, n = 6; P less than 0.001) at constant steady‐state intravenous test concentrations (mean 15.0 +/‐ 1.6 micrograms/ml after chronic oral dosing), excluding significant concentration dependence. Extrapolation of acute clearance findings to maintenance requirement may not be valid even in the same individual, with theophylline therapy requiring on‐going review beyond acute stabilisation.