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Pharmacokinetics of digoxin alone and in the presence of indomethacin therapy.
Author(s) -
Finch MB,
Johnston GD,
Kelly JG,
McDevitt DG
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02353.x
Subject(s) - digoxin , pharmacokinetics , medicine , pharmacodynamics , pharmacology , distribution (mathematics) , drug interaction , renal function , heart failure , mathematical analysis , mathematics
The effects of maintenance indomethacin therapy on single dose digoxin pharmacokinetics and dynamics were studied in six healthy volunteers with normal renal function. Indomethacin did not alter the elimination half‐life, systemic clearance or distribution of digoxin. No pharmacodynamic interaction as assessed by changes in the systolic time intervals QA2 and LVET was found. This study does not lend support for a significant digoxin‐indomethacin interaction in man.