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Comparison of the effects of prizidilol and propranolol on renal haemodynamics at rest and during exercise.
Author(s) -
Malini PL,
Strocchi E,
Ambrosioni E
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02339.x
Subject(s) - propranolol , medicine , renal blood flow , renal function , hemodynamics , blood pressure , placebo , rest (music) , heart rate , essential hypertension , cardiology , effective renal plasma flow , urology , anesthesia , endocrinology , alternative medicine , pathology
Effective renal plasma flow and glomerular filtration rate were measured in 22 mild‐to‐moderate, uncomplicated, essential hypertensive patients during placebo and after 3 months of randomly assigned treatment either with prizidilol (n = 10) or propranolol (n = 12). Measurements were performed at rest and during cycloergometer exercise. For a comparable effect on blood pressure effective renal plasma flow was significantly increased at rest by prizidilol (+9%) and decreased by propranolol (‐13.6%); these patterns were maintained during exercise. Glomerular filtration rate was immodified after the treatment with both drugs. It is concluded that prizidilol is an effective hypotensive agent with no deleterious effects on renal haemodynamics.