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Suppression of plasma cortisol after oral administration of oxazepam in man.
Author(s) -
Gram LF,
Christensen L,
Kristensen CB,
KraghSorensen P
Publication year - 1984
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1984.tb02335.x
Subject(s) - oxazepam , oral administration , endocrinology , medicine , oral dose , hydrocortisone , plasma concentration , plasma levels , pharmacology , chemistry , benzodiazepine , receptor
In seven healthy male subjects plasma cortisol was measured at 20 min intervals from 07.00 to 13.00 h, during a drug free control test and after oral administration of 30 and 60 mg oxazepam. A significant suppression of the plasma cortisol levels for about 2 h after 30 mg oxazepam, and for about 3 h after 60 mg oxazepam was observed. The suppression wore off before the oxazepam plasma concentration started to decline significantly.