Premium
Inhibition of pentagastrin‐stimulated and overnight gastric secretion by mianserin.
Author(s) -
Wilson JA,
Read J.R.,
Boyd EJ,
Wormsley KG
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb05882.x
Subject(s) - pentagastrin , mianserin , pepsin , secretion , medicine , gastric acid , endocrinology , chemistry , biochemistry , serotonin , enzyme , receptor
1 The effects of mianserin (60 mg) have been studied on nocturnal and pentagastrin‐stimulated gastric secretion. 2 Mianserin reduced pentagastrin‐stimulated gastric acid secretion by 38%, pepsin by 40% and secretory volume by 45% during a 1 h test. 3 Twelve‐hour overnight secretion of acid was reduced by 37%, while secretion of pepsin was reduced by 43% and secretory volume by 51%. 4 No adverse effects were noted. 5 These findings, which achieve statistical significance, suggest the need for further study to evaluate the possible role of mianserin in the therapy of duodenal ulcer disease.