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Antidepressant drugs, convulsions and epilepsy.
Author(s) -
Richens A.,
Nawishy S.,
Trimble M.
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb05878.x
Subject(s) - mianserin , convulsant , antidepressant , pharmacology , monoamine oxidase , monoamine oxidase inhibitor , epilepsy , medicine , chemistry , enzyme , receptor , psychiatry , biochemistry , hippocampus
1 Evidence concerning the convulsant effects of non‐monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non‐monoamine oxidase inhibitor antidepressant drugs. 4 Enzyme‐inducing anti‐epileptic drugs can reduce the peak plasma concentration of mianserin and shorten its elimination half‐life, probably by inducing its metabolism.