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Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam.
Author(s) -
Goetzke E,
Findeisen P,
Welbers IB
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02318.x
Subject(s) - triazolam , medicine , rebound effect (conservation) , hypnotic , anesthesia , drug tolerance , benzodiazepine , pharmacology , receptor , efficient energy use , electrical engineering , engineering
Efficacy of and tolerance to 0.25 mg brotizolam and 0.25 mg triazolam were compared in hospitalised patients (aged 20 to 69 years) with sleep difficulties. Over 6 days there were no differences in efficacy and tolerance. The physicians reported the effectiveness of the drugs as good‐to‐satisfactory in 88.6% with brotizolam and 92.0% with triazolam. The patients reported with both drugs reduced time to fall asleep, less awakenings, increased duration of sleep and improved condition on awakening.