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Comparative studies on the efficacy of brotizolam and nitrazepam: a multi‐centre study.
Author(s) -
Lohmann H,
Delbruck O,
Findeisen P
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02317.x
Subject(s) - nitrazepam , tolerability , medicine , hypnotic , sleep onset latency , anesthesia , sleep quality , pharmacology , insomnia , diazepam , adverse effect
Efficacy and tolerability of brotizolam (0.25 and 0.5 mg) were compared over a 6‐day period with nitrazepam (5.0 mg) in middle‐aged patients (less than 65 years) with sleep disturbances requiring medication. The study was double‐blind and randomised with a cross‐over design. Each preparation reduced sleep onset latency and frequency of awakenings, and improved quality and duration of sleep as well as subjective condition on awakening. Brotizolam 0.25 mg was found to be equally effective as 0.5 mg, and so the lower dose is recommended for the middle aged.