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Effects of brotizolam on the sleep of chronic insomniacs.
Author(s) -
Mamelak M,
Csima A,
Price V
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02313.x
Subject(s) - insomnia , medicine , sleep (system call) , anesthesia , sleep stages , slow wave sleep , sleep induction , hypnotic , rapid eye movement sleep , polysomnography , eye movement , pharmacology , electroencephalography , psychiatry , apnea , operating system , ophthalmology , computer science
Effects of 0.5 mg brotizolam on the sleep of chronic insomniacs were assessed electroencephalographically and subjectively over 14 days. Brotizolam (0.5 mg) increased total sleep time, decreased drowsy (stage 1) sleep and increased stage 2 sleep. At this dose it also decreased slow wave and rapid eye movement sleep. On withdrawal there was evidence of insomnia in some subjects during the first night. The drug was well tolerated. Further studies are indicated with lower doses of the drug.