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Residual effects of flurazepam and brotizolam on psychomotor performance.
Author(s) -
Krueger H,
MullerLimmroth W
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02309.x
Subject(s) - flurazepam , placebo , psychomotor learning , medicine , poison control , psychiatry , medical emergency , benzodiazepine , cognition , alternative medicine , pathology , receptor
Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo‐motor coordination, visuo‐mental processing time, visuo‐motor reaction time and reading errors were not impaired with brotizolam. There were residual effects with 30 mg flurazepam. Visuo‐motor coordination, visuo‐mental processing time, visuo‐motor reaction time, and reading errors were impaired compared with placebo and 0.25 mg brotizolam. Subjective assessments of performance correlated with measured performance. There was a decrease with flurazepam (visuo‐motor coordination and visuo‐mental processing time) compared with placebo.