Premium
Kinetics of 5‐aminosalicylic acid after jejunal instillation in man.
Author(s) -
Nielsen Haagen O,
Bondesen S
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02254.x
Subject(s) - aminosalicylic acid , pharmacokinetics , metabolite , absorption (acoustics) , moiety , acetylation , chemistry , pharmacology , active metabolite , medicine , biochemistry , stereochemistry , physics , acoustics , gene
The human pharmacokinetics of 5‐aminosalicylic acid (5‐ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5‐ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.