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Acute treatment of hypertensive crisis with nifedipine.
Author(s) -
Huysmans FT,
Sluiter HE,
Thien TA,
Koene RA
Publication year - 1983
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1983.tb02250.x
Subject(s) - nifedipine , blood pressure , hypertensive crisis , hypertensive encephalopathy , medicine , heart rate , anesthesia , complication , encephalopathy , renal function , cardiology , calcium
Ten patients with a hypertensive crisis and a decreased renal function were treated with 10 (n = 7) or 20 (n = 3) mg nifedipine sublingually. Blood pressure was reduced in 60 min from 211 +/‐ 4/134 +/‐ 5 to 172 +/‐ 6/107 +/‐ 6 mm Hg. The decrease of blood pressure was accompanied by a rise in heart rate from 83 +/‐ 6 to 98 +/‐ 5 beats/min. In all seven patients with an encephalopathy signs of this complication were reduced. No serious side‐effects were observed.